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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1972 2
1974 1
1975 1
1976 1
1979 1
1980 1
1984 5
1985 1
1987 4
1988 6
1989 4
1990 6
1991 2
1992 1
1993 4
1994 2
1995 4
1996 5
1997 6
1998 2
1999 8
2000 13
2001 16
2002 17
2003 18
2004 21
2005 26
2006 32
2007 27
2008 29
2009 27
2010 34
2011 34
2012 36
2013 40
2014 45
2015 40
2016 37
2017 35
2018 48
2019 46
2020 49
2021 61
2022 54
2023 35
2024 23

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839 results

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Page 1
Five-Membered Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors.
Angeli A, Paoletti N, Supuran CT. Angeli A, et al. Molecules. 2023 Apr 4;28(7):3220. doi: 10.3390/molecules28073220. Molecules. 2023. PMID: 37049983 Free PMC article. Review.
In particular, five-membered heterocyclic sulfonamides have been generally shown to be more effective inhibitors compared to six-membered rings ones. Despite the importance of oxygen and nitrogen five-membered heterocyclic aromatic rings in medicinal chemistr …
In particular, five-membered heterocyclic sulfonamides have been generally shown to be more effective inhibitors compared to six-memb …
Fused 1,5-Naphthyridines: Synthetic Tools and Applications.
Masdeu C, Fuertes M, Martin-Encinas E, Selas A, Rubiales G, Palacios F, Alonso C. Masdeu C, et al. Molecules. 2020 Jul 31;25(15):3508. doi: 10.3390/molecules25153508. Molecules. 2020. PMID: 32752070 Free PMC article. Review.
These syntheses are classified according to the nature of the cycle fused to the 1,5-naphthyridine ring: carbocycles, nitrogen heterocycles, oxygen heterocycles, and sulphur heterocycles. In addition, taking into account the aforementioned versa …
These syntheses are classified according to the nature of the cycle fused to the 1,5-naphthyridine ring: carbocycles, nitrogen het …
Structure-guided insights into heterocyclic ring-cleavage catalysis of the non-heme Fe (II) dioxygenase NicX.
Liu G, Zhao YL, He F, Zhang P, Ouyang X, Tang H, Xu P. Liu G, et al. Nat Commun. 2021 Feb 26;12(1):1301. doi: 10.1038/s41467-021-21567-9. Nat Commun. 2021. PMID: 33637718 Free PMC article.
Biodegradation of aromatic and heterocyclic compounds requires an oxidative ring cleavage enzymatic step. Extensive biochemical research has yielded mechanistic insights about catabolism of aromatic substrates; yet much less is known about the reaction mechanisms un …
Biodegradation of aromatic and heterocyclic compounds requires an oxidative ring cleavage enzymatic step. Extensive biochemica …
Pharmacological activity and mechanism of pyrazines.
Hou W, Dai W, Huang H, Liu SL, Liu J, Huang LJ, Huang XH, Zeng JL, Gan ZW, Zhang ZY, Lan JX. Hou W, et al. Eur J Med Chem. 2023 Oct 5;258:115544. doi: 10.1016/j.ejmech.2023.115544. Epub 2023 Jun 5. Eur J Med Chem. 2023. PMID: 37300915 Review.
Heterocycles are common in the structure of drugs used clinically to deal with diseases. ...These properties often bring enhanced target binding ability to these compounds when compared to alkanes. Pyrazine is a nitrogen-containing six-membered heterocyclic ring …
Heterocycles are common in the structure of drugs used clinically to deal with diseases. ...These properties often bring enhanced tar …
Synthesis and Biological Evaluation of Oxygen-containing Heterocyclic Ring-fused 23-Hydroxybetulinic Acid Derivatives as Antitumor Agents.
Zhang H, Li F, Zhu P, Liu J, Yao H, Jiang J, Ye W, Wu X, Xu J. Zhang H, et al. Chem Biol Drug Des. 2015 Oct;86(4):424-31. doi: 10.1111/cbdd.12543. Epub 2015 Mar 6. Chem Biol Drug Des. 2015. PMID: 25688519
Most of the newly synthesized compounds exhibited more potent antiproliferative activity than patent compound 23-hydroxybetulinic acid, especially 13e and 14a were about four- to sevenfold more potent against all tested cancer cell lines than 23-hydroxybetulinic acid. Furt …
Most of the newly synthesized compounds exhibited more potent antiproliferative activity than patent compound 23-hydroxybetulinic acid, espe …
Xanthones: A Class of Heterocyclic Compounds with Anticancer Potential.
Gul S, Aslam K, Pirzada Q, Rauf A, Khalil AA, Semwal P, Bawazeer S, Al-Awthan YS, Bahattab OS, Al Duais MA, Thiruvengadam M. Gul S, et al. Curr Top Med Chem. 2022;22(23):1930-1949. doi: 10.2174/1568026622666220901145002. Curr Top Med Chem. 2022. PMID: 36056870 Review.
Xanthones (9H xanthen-9-one) are an important class of heterocyclic compounds containing oxygen and a moiety of gamma-pirone, dense with a two-benzene ring structure, distributed widely in nature. ...The major class of xanthones includes simple oxygenated …
Xanthones (9H xanthen-9-one) are an important class of heterocyclic compounds containing oxygen and a moiety of gamma-pirone, …
Therapeutic Journey and Recent Advances in the Synthesis of Coumarin Derivatives.
Sinha S, Singh K, Ved A, Hasan SM, Mujeeb S. Sinha S, et al. Mini Rev Med Chem. 2022;22(9):1314-1330. doi: 10.2174/1389557521666211116120823. Mini Rev Med Chem. 2022. PMID: 34784861 Review.
OBJECTIVE: This review provides detailed information regarding the studies focused on the recent advances in various pharmacological aspects of coumarins. METHODS: Various oxygen-containing heterocyclic compounds represent remarkable biological significance. ...Coum …
OBJECTIVE: This review provides detailed information regarding the studies focused on the recent advances in various pharmacological aspects …
Ene cyclization reaction in heterocycle synthesis.
Saha P, Saikia AK. Saha P, et al. Org Biomol Chem. 2018 Apr 25;16(16):2820-2840. doi: 10.1039/c8ob00429c. Org Biomol Chem. 2018. PMID: 29594296 Review.
The ene cyclization has evolved to become an indispensable tool for the synthesis of various ring size heterocyclic compounds. In the past and recent years, many exciting reports have demonstrated the broad scope and synthetic utility of ene cyclization and the vers …
The ene cyclization has evolved to become an indispensable tool for the synthesis of various ring size heterocyclic compounds. …
Chromenes - A Novel Class of Heterocyclic Compounds: Recent Advancements and Future Directions.
Chaudhary A, Singh K, Verma N, Kumar S, Kumar D, Sharma PP. Chaudhary A, et al. Mini Rev Med Chem. 2022;22(21):2736-2751. doi: 10.2174/1389557522666220331161636. Mini Rev Med Chem. 2022. PMID: 35362382 Review.
Chromenes are an important class of oxygen-containing heterocyclic compounds with intriguing biological activity, a simple structure with mild adverse effects. ...Substitution at the 7th position with electron donating group enhances the pharmacological activity whe …
Chromenes are an important class of oxygen-containing heterocyclic compounds with intriguing biological activity, a simple str …
Decoration of A-Ring of a Lupane-Type Triterpenoid with Different Oxygen and Nitrogen Heterocycles.
Sousa JLC, Albuquerque HMT, Silvestre AJD, Silva AMS. Sousa JLC, et al. Molecules. 2022 Jul 31;27(15):4904. doi: 10.3390/molecules27154904. Molecules. 2022. PMID: 35956853 Free PMC article.
Remarkably, the triterpene acts as a diastereoselective inducer in the conjugate addition of nitromethane, originating only one diastereomer out of four possible ones. Furthermore, other oxygen and nitrogen-containing heterocycles were installed at the A-ring …
Remarkably, the triterpene acts as a diastereoselective inducer in the conjugate addition of nitromethane, originating only one diastereomer …
839 results